Feb 012011

Un estudio realizado por centros de investigación estadounidenses, canadienses y holandeses ha mostrado que la enfermedad celíaca y el mal de Crohn comparten por lo menos cuatro localizaciones genéticas que aumentan el riesgo de que el portador desarrolle alguna de estas enfermedades.

Los científicos hicieron un meta-análisis combinado de datos genómicos de las mencionadas enfermedades e identificaron dos nuevas localizaciones de riesgo compartidas y dos que ya habían sido identificadas de forma independiente en cada enfermedad.

El origen de estas enfermedades  solamente se conoce en parte, aunque se sabe que hay factores de riesgo genéticos y ambientales implicados en su desarrollo. Al menos un uno por ciento de los individuos del mundo occidental desarrollará enfermedad celiaca y aunque la enfermedad de Crohn es mucho menos común, puede estar acompañada por síntomas muy graves al afectar a todo el tracto gastrointestinal.

En anteriores ocasiones se ha demostrado que los pacientes celiacos se encuentran bajo un mayor riesgo de desarrollar enfermedad de Crohn, por lo que se ha considerado la posibilidad de que ambos trastornos compartan localizaciones genéticas de riesgo.

Los investigadores concluyen que, aunque se necesitan estudios adicionales para conocer los mecanismos por los que estas variantes genéticas influyen en la enfermedad de Crohn y la enfermedad celiaca, el estudio actual proporciona una prueba primordial de que se pueden identificar factores de riesgo compartidos entre enfermedades relacionadas mediante la combinación de datos genéticos procedentes de enfermedades distintas clínicamente.

En el trabajo han participado investigadores de la Universidad de Groningen, en los Países Bajos; el Instituto Broad, en Estados Unidos; y la Universidad y el Instituto del Corazón de Montreal en Canadá.

  3 Responses to “La enfermedad de Crohn y la Celiaquía comparten rasgos genéticos.”

  1. Its often hard to get proper tmtnereat for chronic illness, because a lot of time you look fine on the outside. Its like people forget there is a whole inside where havoc is going on.I grew up in Michigan and was diagnose with my first autoimmune disorder at the age of 15 (severe psoriatic arthritis). This was not surprising as my father had more that one AI problem including severe Chrons. The doctor I had in Michigan was fantastic. I had seen him basically my whole life. He took my pain very seriously and managed it well. Never made me feel like less of a person or untrustworthy. He never once humiliated me. I was his patient for over 20 years. I was also naive and though most other doctors treated their patients with this type of respect. Even the specialist referrals weren’t truamatic.I became disabled in 2005.I decided to move to California 3 years ago and boy did I find out things were different. I figured it would be easy just to transfer records and set up shop with a new doctor, I couldnt have been more wrong. I interviewed a lot of doctors upon arriving because I kept being called a liar, a drug seeker, that I didnt want to get better. I have MRI’s covering 8 years I brought to all these appointments that clearly showed the progression of the arthritis, along with degenerative disc disorder. I was still shoved out of their offices in tears because I wasnt being believed. Granted they would give me a script for the bare minimum when it came to pain management but didnt want to stick with the tmtnereat plan that actually gave me a life. One pain doctor wanted to cut me open before he saw the MRI’s. There is nothing surgically to do. He made sure to humiliate me every time I went in, once even handing me a urine cup when I know it wasnt in the contract! After him I continued to try and find a fit for me. Doctors came and went and it always seemed to go the same here is your pain medication, now here is your humiliation. In this time I developed Chrons and hypothyroid which were overlooked, because I wasnt taken seriously.I have finally put together a group of professionals I trust, starting with my GP. He treats my pain seriously and wants me to be comfortable even if it means I am in his office a lot. He ALWAYS calls back.He is also not afraid to be aggressive with it, and it was like that from the first visit. My GI doc is fantastic as well. I feel very safe now with my team. I also always take someone in the office with me because if I am going to be mistreated I want witnesses and someone who will speak up for me as I just tend to cry.Some of this medical hell has added to my PTSD, I was labeled a drug seeker, they treated me no better than my verbally abusive mother. Major illnesses were overlooked because of their bias. People shouldnt have to suffer because doctors have bias.Its not only doctors that have treated me this way. Nurses, pharmacists, etc. One pharmacist was so out of line my advocate reported him to the state board.If you are frustrated with your doc keep looking. I drive an extra 20 miles to see mine,I know not everyone can do that, it can be worth it though. It takes so much energy to be chronically ill that energy doesnt need to be wasted on medical professionals that dont want to help.

  2. Thank you for speaking out for minloils of us with bowel disease. Fortunately I fall on the lighter end of the spectrum (but it does not seem light to me) I also have Fibromyalgia which messes with your gut. For thirty plus years I have been Dx’d IBD, no IBS, no Crone’s Disease. All I know for all the doctors, meds and hospitalations is that probably 70% of the time my gut hurts. I was once told that I had to make an appointment with a Gastroenterologist that coincided with the painful attacks. No way could he understand that when I was in the middle of an attack I was rolled in a ball in the bathroom floor entirely too ill to drive across Denver Colorado to see him. He also could not explain how to make these appointments so he could see me in the middle of an episode. Hopefully you will help legitimize bowel diseases, including those that come with Fibromyalgia, and allow us to walk into a physicians office without the raised eyebrow, when you say you need pain medication.

  3. I wish you all the best with your endeavors and know that if you put your full heart into it it can be aceihved. :)It’s so easy sometimes to say that we are too busy, and then a month later wonder why something hasn’t gotten done or aceihved, I have that problem too. Things fall by the wayside and we wonder why and how to pick them back up again. Good luck, Cyn![]

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